5.01 MD-PhD Program


The mission of the Harvard/MIT MD-PhD Program is to train the next generation of physician-scientist leaders, with representation across a rich diversity of premier clinical disciplines and research areas, spanning basic, translational, bioengineering and social sciences. The MD-PhD Program integrates training in both medicine and research for students who intend to pursue careers as physician-scientists.

The MD-PhD Program has established a thriving academic and social environment to support the personal and professional development of each student. Based on the core philosophy that MD-PhD students should be educated as physician-scientists from matriculation to graduation, the program integrates training in scientific methods and research into the medical school curriculum. By combining the HST, New Pathway or Pathways MD program (Sections with a graduate program of interest, students design their own courses of study. MD-PhD advisors supervise choices in consultation with graduate program advisors.

The MD-PhD Program is supported in part by the National Institutes of Health (NIH) through its Medical Scientist Training Program (MSTP). The MSTP grant, along with other sources, provides scholarship support, at least in part, for many of the students who are pursuing combined MD-PhD degrees.

Affiliate Program

Students who enter HMS as MD students and decide after admission to pursue both the MD and a PhD degree are eligible to apply for affiliate status in the MD-PhD Program. The application for affiliate status is available on eCommons via the MD-PhD Program. Students are encouraged to apply in their first year of medical school, or as soon as they have decided to pursue this course of study. MD students who applied MD-PhD are invited to affiliate early and participate in our summer course before starting medical school.  MD students who did not apply are welcome to affiliate after November 1 of their M1 year. Admission to the affiliate program is on a rolling basis. Students with affiliate status are invited to participate in all MD-PhD activities.

Maintenance of affiliate status is dependent on achieving relevant benchmarks, such as completion of laboratory rotations or mentored research; application and acceptance to a graduate program; and satisfactory completion of medical and graduate school requirements.

Students who have affiliate status are not funded by the MD-PhD Program prior to starting graduate school but are eligible to apply for second cycle funding for their remaining medical school years in the winter before they return to medical school. There is no guarantee of funding, but the program makes every effort to provide full or partial support to qualified applicants during their M3 and M4 years. Cycle II applicants who are eligible for NIH F30/F31 fellowships are required to submit such grant applications in order to be considered for cycle II funding. The fellowship proposal is usually submitted in the first or second year of graduate school.

MD-PhD Curriculum Overview

The educational curriculum for MD-PhD students usually follows a “2-4-2” model. Training begins in the summer before the first year of medical school with a course called “Molecular Biology of Human Disease,” designed to introduce students to current disease-oriented research problems in the biomedical sciences and to develop their critical thinking skills. All MD-PhD students are required to take pre-PhD clinical clerkships for credit during the M2 year alongside their MD classmates (3 months for HST, 9 months for Pathways). The MD-PhD Program offers a ReIntroduction to Clinical Medicine as a special elective to facilitate the transition back to medical school following the PhD. This course is required. Please refer to the respective curriculum maps for timeline specifics.

The MD-PhD program also offers many enrichment and social activities, such as community gatherings, annual retreats, informal dinners with faculty, a peer-to-peer Big Sib program, MD-PhD Grand Rounds, and a clinical problem solving and "Meet the Investigator” seminar series. Students pursuing social science research are fully integrated into the Harvard/MIT MD-PhD Program and, due to their unique research travel experiences, are also offered the opportunity to apply for summer scholarship awards. In total, these programmatic activities both build cohesion and community among all program students and faculty, and foster peer-to-peer and faculty mentoring relationships dedicated to the MD-PhD cohort of Harvard medical students.

Please note that to be granted the MD degree MD-PhD Students must complete all course and examination requirements in the New Pathway, Pathways, or London HST Programs (See Section 1.03, Course and Examination Requirements for the MD Program). The MD curriculum does not permit MD-PhD students to waive any courses required for the MD degree.

Responsible Conduct in Research

MD-PhD students, irrespective of funding support, are required to receive instruction in general areas of medical ethics and the responsible conduct and publication of scientific research. Courses such as Medical Sciences 300: Conduct of Science, offered by the HMS Division of Medical Sciences (DMS), or HPM548, offered by the Harvard School of Public Health (HSPH), meet this requirement. Most graduate programs also require such a course. The MD-PhD Program office annually completes a thorough review of MD-PhD students and reaches out, as needed, to ensure compliance. Students in graduate programs that do not have this requirement will be enrolled in the DMS course or its equivalent.

Time to Degree

Requirements for both the MD and PhD degrees should be completed in an average of seven to eight years. Ordinarily a student in the MD-PhD Program will not be permitted to remain at HMS beyond 10 years (See Section 2.08Policy on Length of Time to Complete the MD Degree). A MD-PhD student who wishes to extend his/her training beyond a total of nine years for both degrees will need to petition the MD-PhD Program for approval, providing appropriate justification for the extension of time needed to complete both degrees and a plan and timeline for completion. A student who has a compelling case for extending the MD-PhD beyond ten years must work with his/her Society Advisor to petition the HMS Promotion and Review Board to approve an extension and must submit at that time a detailed plan and timeline for completing the requirements of both degrees.

Other issues to consider while planning your schedule are outlined in Section 1.03: Course and Examination Requirements for the MD Degree.

  • The minimum clinical-month requirement for licensing in the state of Massachusetts is 14 clinical months. The state of California requires 18 clinical months for licensure. In addition to the clinical courses taken,Patient-Doctor II (New Pathway), Practice of Medicine (Pathways) or Introduction to Clinical Medicine (HST) count for 2 clinical months in California. Lastly and very importantly, California has a Family Practice requirement. The Primary Care Clerkship meets the Family Practice requirement. For MD licensure purposes, HMS students must be able to document four years of full-time residence in medical school. Consult with the HMS Registrar if you have concerns about meeting medical school enrollment requirements.
  • Early Match programs include Ophthalmology, Urology and some plastic surgery programs. For more detailed information, please refer to the HMS website Career Advising: Roadmap to Residency.
  • All MD students are required to pass USMLE Step 1 and USMLE Step 2 CK in order to graduate. Because of limitations in the availability of test slots and the extended reporting timeline for Step 2 test results, HMS requires that they take CK by December 31 to ensure the results will be posted prior to rank.Students should be aware that some residency programs may require that students have passing scores available for all parts of USMLE, by the rank order deadline for the residency match (late February) in order to be considered for ranking by the program. Students should check directly with the residency programs for specific requirements. 
  • To receive the MD degree, test scores must be reported to the HMS Registrar. If a student's passing scores are not reported to the HMS Registrar before graduation, that student will not receive the MD degree at graduation. Because failure to receive the MD degree will have an impact on a student's ability to start postgraduate training, the Academic Societies require students to confirm their test schedules as they prepare the MSPE (Medical Student Performance Evaluation); failure to schedule the test before the HMS deadline may be noted in the Dean's Letter. To learn more about resources available to help with study strategies, exam taking, etc., see Section 3.01Office of Learning Resources and Support.
  • The MSPE (Medical Student Performance Evaluation) is sent on October 1.

Application Process for Funding

The MD-PhD Program welcomes applications from all qualified students, including students who are underrepresented in medicine, students with disabilities, and students from socio-economically disadvantaged backgrounds. The program is committed to enrolling a diverse body of talented students.

Two application cycles are available during the academic year.

The first cycle is for applicants applying for simultaneous admission to the MD-PhD Program and to Harvard Medical School through either the HMS Pathways program or the HST program. 

The second cycle is for unfunded MD-PhD affiliate students currently enrolled in the Pathway or HST program. Second cycle application forms are available on eCommons via the MD-PhD Program. Affiliate medical students are not eligible to apply for second cycle funding until the final year of the PhD. If awarded, full or partial funding of tuition/fees and stipend is provided for the last two years of medical school only.

Evaluation of applicants for admission to the MD-PhD Program is based on a rigorous review of all materials submitted as part of the MD-PhD Program application. The admissions committee seeks applicants with outstanding academic ability and demonstrated commitment to pursue careers that will have a significant positive impact on human health including academic medicine and research, in industry and government. The most competitive applicants typically have a combination of substantial research experience, evidence of clinical commitment, special talents and accomplishments, and leadership potential. Applicants selected for interviews will meet with MD-PhD program faculty dedicated to the admissions process. Final decisions are made in March.

Advice on Graduate Programs

The MD-PhD Program application does not replace the formal application required for graduate school which is usually made during the second year of the MD-PhD Program.

Requirements for admission and specific application procedures vary according to the individual graduate programs. Students are strongly advised to contact representatives of the graduate programs to consult about selection and specific requirements. Some graduate programs may require the Graduate Record Examination (GRE). In addition, some PhD student fellowships may require the GRE.

Course requirements vary among programs. Completing one or more graduate courses during the first two years at HMS is helpful, if feasible. Courses should be chosen in consultation with faculty from the graduate program. Depending on the program, medical school courses may fulfill certain graduate course requirements.

During the graduate years, MD-PhD students are supported by funds available from the individual graduate programs, special fellowships and research assistantships. Students who do not receive MSTP support prior to beginning a graduate program are required to apply for individual fellowships offered by the NIH and other funding agencies, if eligible, in order to be considered for cycle II funding. Administrators in the graduate program and the MD-PhD Program office are available to advise students about funding opportunities.

Most biomedical graduate programs require at least two laboratory rotations, usually with faculty members associated with their program (i.e., rotations with other faculty may not “count” toward the program rotation requirement). These may be completed prior to enrollment in the graduate program, if feasible. One rotation will be in the lab that the student ultimately chooses for thesis work. Lab rotations, which may be conducted at any time during the year, typically involve at least a 25% time commitment to a lab for a period of 6–14 weeks. To obtain credit for a rotation in DMS, a student must complete a rotation form, which must also be signed by the rotation advisor. The form can be found on the MD-PhD eCommons page or requested from the MD-PhD Program office.

Leaves of Absence: Policies regarding leaves of absence (LOA) vary depending on the student’s stage in training. In addition to the respective program’s approval (e.g., MD, PhD [GSAS, MIT]), approval for an LOA from the Director of the MD-PhD Program is also required. Students in the graduate school phase of training should also notify their medical school Society Advisor about any extended time away from the PhD program to discuss the implications for his/her medical training and what, if any, further review or approval is needed by the Program in Medical Education.


  • Student Handbook Sections:
  • 2.09: Leaves of Absences
  • 2.07Full or Part Time Status Requirements
  • 2.08Policy on Length of Time to Complete the MD Degree
  • 2.19: Satisfactory Academic Progress

GSASDegree requirements

MITChanges in registration

For further information, please contact:

MD-PhD Program
Harvard Medical School
260 Longwood Avenue, TMEC, Room 168
Boston, MA 02115
Telephone:    617-432-0991
Fax :               617-432-2791
E-mail:           mdphd@hms.harvard.edu

Website:       http://www.hms.harvard.edu/md_phd/

Last updated 4/16/21